Carol’s paper titled “Chromatin Tracing: Imaging 3D Genome and Nucleome” is recognized as one of the fifteen “Best of 2021” papers published in Trends in Cell Biology, and is the only forum article on the list. Big congratulations again, Carol!
We are excited to have Ruihuan Yu, MSc joining us as a postgraduate research fellow. Ruihuan grew up and studied Clinical Medicine as an undergraduate in China. She recently graduated from Laurentian University with an MSc in Chemical Science, Chemistry and Biochemistry. During her graduate study, Ruihuan led a research on lipid overload-induced cardiac senescence. She examined the effects of H2S on protein acetylation and lipid overload-induced mitochondrial dysfunction, and revealed the regulatory mechanism of how H2S could prevent ageing- and obesity-related heart diseases. Ruihuan is extremely interested in our lab’s research on spatial transcriptomics and 3D genome organization with image-based spatial omics technologies including chromatin tracing, MERFISH, and MINA. She is very excited to start this new chapter of her research career in Wang lab. Besides science, Ruihuan enjoys working out, reading, exploring delicious food, and playing Ping-Pong. At Yale, she also hopes to find new friends to learn swimming together. Welcome to our lab, Ruihuan!
Our paper on TAD-like structures (also known as single-cell domains) on human active and inactive X chromosomes is published in Genome Biology. We show that these structures may not depend on interactions mediated by major epigenetic marks. Congrats again to co-first authors Yubao and Miao!
Yubao Cheng*, Miao Liu*, Mengwei Hu & Siyuan Wang, TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations, Genome Biology, Volume 22, Number 309, (2021). *Co-first authors. (Link).
We thank Yale School of Medicine for featuring our new grant from the new NIH Common Fund SenNet Program and look forward to working with Dr. Nicola Neretti from Brown and Dr. Jian Ma from CMU in this exciting collaboration!
https://medicine.yale.edu/news-article/nih-funds-yales-wang-and-colleagues-to-study-senescent-cells/
Our latest collaboration work with Prof. Stefania Nicoli’s lab is posted on bioRXiv (Link)! Very interesting and surprising findings. Congrats to co-first authors Liana and Carol (Mengwei) and the rest of the team! This is Carol’s 3rd first-authored paper after merely 2 years in the lab. Proud to have such amazing students.
Liana Boraas*, Mengwei Hu*, Lauren Thornton, Charles E. Vejnar, Gang Zhen, Antonio J. Giraldez, Christine Mayr, Siyuan Wang# & Stefania Nicoli#, Non-coding function for mRNAs in focal adhesion architecture and mechanotransduction, bioRXiv, doi: https://doi.org/10.1101/2021.10.04.463097, (2021). *Co-first authors. #Co-corresponding authors. (Link).
We are excited to have Dr. Patrick Morley Willoughby joining us as the very first postdoctoral fellow of Wang Lab. Morley was born and raised outside Toronto, Canada and recently graduated from the University of Toronto with a PhD in Cell and Systems Biology. Prior to graduate school, Morley obtained his Honours BSc in Biology from Western University in Ontario. During his doctoral studies, Morley investigated Rab proteins and endosomal biology during epithelial morphogenesis in the early zebrafish gastrula. Specifically, Morley found the epithelial restricted GTPase, Rab25, contained functions related to both local cell behaviours, such as cytokinetic abscission, as well as global tissue material properties including epithelial viscoelasticity. Morley is incredibly excited to begin a new chapter of studies involving spatial transcriptomics and 3D genome organization in Dr. Wang’s lab. Besides science and experiments, Morley enjoys golfing, appreciates food, nature and loves catching up with friends and family on weekends. Welcome, Morley!
Yanfang and Miao’s recent work published in Cell Discovery is now highlighted by Genetic Engineering and Biotechnology News (GEN). Congrats to Yanfang and Miao again!
Spatial Transcriptomics Puts More Biology on the Map
Congratulations to co-first authors Yubao and Miao! This is Yubao’s first work after merely one year in the lab, and Miao’s 4th first-authored paper in her 3 years in the lab. We are very proud for our talented and productive students. Stay tuned for their main graduate works which are yet to be revealed.
Yubao Cheng*, Miao Liu*, Mengwei Hu & Siyuan Wang, TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations, bioRXiv, (2021). * Co-first authors. https://doi.org/10.1101/2021.05.12.443887 (Link).
