Xinlin is a first-year PhD student in the MCGD track of Yale BBS program. She was born in Sichuan, China and earned her bachelor’s degree in Biological Sciences at Nankai University in China. During her undergraduate study, she worked as a student intern in Columbia University and University of California, San Diego for one year, where she focused on developing high-throughput in vivo CRISPR screen platform to identify key regulators of spinocerebellar ataxia diseases. By doing rotation in Wang lab, she hopes to combine cutting-edge chromatin tracing and spatial transcriptomic technologies with CRISPR screen to gain more insights of 3D genome architecture and transcription regulation in cancer. In her spare time, she likes to read books, sing, dance and eating spicy food. Welcome, Xinlin!

Our Yubao was the recipient of the best poster award at the 2023 Yale Genetics Department Annual Retreat. This incredibly marks the third consecutive year winning streak of this award by students from our lab. Well done, Yubao!

Samuel is a PhD student in the Department of Immunobiology. He earned his bachelor’s degree in Life Science from University Pierre and Marie Curie (UPMC, Paris, France), and his Master’s degree in Molecular and Cellular Biology (Major Immunology) from UPMC and Pasteur Institute (Paris, France). Samuel completed his master’s thesis at Imagine Institute (Paris, France) where he studied the genetic basis of primary immune deficiencies. He also worked as a postgraduate in the Department of Immunobiology at Yale University, where he focused on characterizing the functional diversity of circulating neutrophils via a behavioral approach. By interacting with the Wang lab, Samuel aims to further his knowledge about the biology and dynamics of chromatin compaction and its functional impact on immune cells. During his spare time, he likes to satisfy his scientific curiosity by reading different kinds of textbooks and essays from experts in the fields. He also likes to paint, and to do photography. Welcome, Samuel!

Glad to share our new preprint reporting the first single-cell 3D genome atlas of any cancer! (link)

In this work, we report the first application of image-based, real-3D genomics to study cancer and identify an unexpected 3D genome bottleneck during subclonal tumor evolution in the native tissue microenvironment. We further define key regulator and effector genes upstream and downstream of substantial 3D genome reorganization that accompanies histologic progression of lung adenocarcinoma. We expect that applying this approach broadly will have an enormous impact on understanding the epigenetic basis of cancer in situ and will lead to the development of novel diagnostic, prognostic, and therapeutic biomarkers based on the 3D genome.

Our carol successfully defended her PhD on March 2, 2023. This is the FIRST PhD defense of the lab. Such a milestone for both Carol and the lab. All Hail Dr. Hu! Congratulations!

Prof. Wang was selected as the recipient of the 2023 Biophysical Society Early Career Award in Physical Cell Biology. We are deeply honored and thank the award committee for the recognition of our work!