We develop and apply state-of-the-art imaging-based omics approaches to understand the spatial organization of mammalian genome and transcriptome and how they impact cellular states. For more information about our research, please click here. For recorded lectures on our chromatin tracing and MINA technologies: 7-min version, 30-min version; lectures on our Perturb-tracing technology: 10 min, 23 min; a lecture on RAEFISH technology: 13 min; an introductory lecture on the brief history of 3D genome organization research: 15 min; an introductory lecture on the brief history of contemporary 3D genomics technologies: 25 min; a lecture on image-based spatial transcriptomics: 23 min; short introduction videos of the lab: 2 min, 3 min.
Principal Investigator: Siyuan (Steven) Wang, PhD, Associate Professor, Department of Genetics, Department of Cell Biology, Yale School of Medicine, Yale University. (Linkedin) (Yale profile) (中文简介) (CV)
Recent National or International Awards/Grants (as PI):
2024 American Society for Cell Biology Innovation in Research Award
2024-2028 National Human Genome Research Institute R01 Award (HG013503)
2024-2028 National Human Genome Research Institute R01 Award (HG012969)
2024-2029 National Cancer Institute R01 Award (CA292936)
2024-2025 National Cancer Institute Yale SPORE in Lung Cancer (YSILC) P50 Supplement Award (CA196530-10S1)
2023-2026 Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research
2023 Biophysical Society Early Career Award in Physical Cell Biology
2022-2025 Pershing Square Sohn Prize for Young Investigators in Cancer Research
2021-2025 NIH Cellular Senescence Program UG3/UH3 Award (CA268202)
2020-2025 NIH 4D Nucleome Program U01 Award (CA260701)
2020-2024 National Human Genome Research Institute R01 Award (HG011245)
2020-2023 National Cancer Institute R33 Award (CA251037)
2019-2024 NIH Director’s New Innovator Award
2018 MIT Technology Review 35 Innovators Under 35
2016 International Union of Pure and Applied Physics Young Scientist Prize in Biological Physics
Selected Media Reports:
New technique offers bigger and better window into RNA activity in complex tissue
Cancer’s Progress Detailed by 3D Genomic Maps
Regulators of DNA Folding Could Be Targets for Treating Cancer
ASCB Announces 2024 Honorific Awards and Recognition
Three YSM Faculty Win Awards to Support Research in Aging, Geroscience
The Pershing Square Sohn Cancer Research Alliance Awards $4.2M to Seven Emerging Trailblazers in Cancer Research
Spatial Transcriptomics Puts More Biology on the Map
王思远：创新DNA成像技术，探索细胞核内的世界 | 35岁以下科技创新35人榜单人物专栏