Thoreen Laboratory

Cellular and Molecular Physiology / Yale University

About us

mRNAs encode information for making proteins, but can include other instructions as well. Non-coding elements might specify where an mRNA should be localized, when it should be translated, and how long it should last. Our lab studies the mechanisms that detect these elements and use them to control the translation and/or stability of specific mRNAs in response to cell signals. A current focus is to understand their function in coordinating cell growth with changing environments, one of the most complex system-wide puzzles that cells must solve. We use a combination of biochemical, computational and next-generation sequencing strategies to answer these questions. See our current research projects for more information.rectangle_montage

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