Our story on the architecture and mechanism of the Pacinian corpuscle is out on the cover of Science Advances!
Ziokowski LH*, Nikolaev YA*, Chikamoto A, Oda M, Feketa VV, Monedero-Alonso D, Ardasheva AA, Bae SS, Xu CS, Pang S, Gracheva EO, Bagriantsev SN. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11:eadt4837
Our paper on the mechanism of long-term thirst suppression during hibernation is out in Science!
Junkins MS, Feng NY, Merriman DK, Bagriantsev SN, Gracheva EO. Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels. Science 2024, 386, 1048–1055.
Our new pre-print on the structure and function of Pacinian corpuscles is out on BioRxiv!
Ziokowski LH*, Nikolaev YA*, Chikamoto A, Oda M, Feketa VV, Monedero-Alonso D, Ardasheva AA, Bae SS, Xu CS, Pang S, Gracheva EO, Bagriantsev SN. Structural and functional dissection of the Pacinian corpuscle reveals an active role of the inner core in touch detection. BioRxiv 2024, https://doi.org/10.1101/2024.08.24.609509
Our paper on the neurophysiological mechanism of long-term anorexia during hibernation is out in Nature Communications!
Mohr SM, Dai Pra R, Platt MP, Feketa VV, Shanabrough M, Varela L, Kristant A, Cao H, Merriman DK, Horvath TL, Bagriantsev SN, Gracheva EO. Hypothalamic thyroid hormone deficiency underlies reversible anorexia in ground squirrels during hibernation. Nature Communications 2024, 15:5803.
Our collaborative paper with Yoshifumi Yamaguchi, Gen Kurosawa and others on the timing of hibernation is out in npj Biological Timing and Sleep!
Gibo S, Yamaguchi Y, Gracheva EO, Bagriantsev SN, Tokuda IT, Kurosawa G. Frequency-modulated timer regulates torpor-arousal cycles during hibernation in distinct small mammalian hibernators. npj Biol Timing Sleep 2024, 1:3.
Maddy and Jenny’s paper on the neural control of fluid homeostasis during hibernation is out in Current Biology!
Junkins MS*, Feng NY*, Murphy LA, Curtis G, Merriman DK, Bagriantsev SN, Gracheva EO. Neural control of fluid homeostasis is engaged below 10°C in hibernation. Current Biology 2024, 34, 1-8.
Our paper on the structure and functional mechanism in Meissner corpuscle is out in Science Advances!
Nikolaev YA*, Ziolkowski LH*, Pang S, Li W-P, Feketa VV, Xu CS, Gracheva, EO, Bagriantsev SN. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle. Science Advances, 2023, 9:eadi4147.
Our review on thermoregulation in hibernators is out in Trends in Neuroscience!
Feketa VV, Bagriantsev SN, Gracheva EO. Ground squirrels — experts in thermoregulatory adaptation. Trends in Neurosciences 2023, https://doi.org/10.1016/j.tins.2023.04.008
Mai and Yury’s collaborative work with the Sobolevsky lab is out in Nature Communications!
Neuberger A, Oda M, Nikolaev YA, Nadezhdin KD, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14, 2451.
A new pre-print from our lab by Yury and Luke reports the structure of Meissner corpuscle and the amazing bi-cellular mechanism by which corpuscles detect touch.
Nikolaev YA, Ziolkowski LH, Pang S, Li W-P, Feketa VV, Xu CS, Gracheva, EO, Bagriantsev SN*. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle. (2023) bioRxiv doi.org/10.1101/2023.04.05.535701.
A new study by Sarah Mohr is out on BioRxiv!
Mohr SM, Dai Pra R, Platt MP, Feketa VV, Shanabrough M, Varela L, Kristant A, Cao H, Merriman DK, Horvath TL, Bagriantsev SN, Gracheva EO. Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator. bioRxiv 2023.03.15.532843; doi: https://doi.org/10.1101/2023.03.15.532843
Our paper on mechanotransduction in the afferent terminal is highlighted by eLife!
Luke’s study on mechanotransduction in nerve terminals is out in eLife!
Ziolkowski LH, Gracheva EO, Bagriantsev SN. Mechanotransduction events at the physiological site of touch detection. eLife 2023, 12:e84179.
Luke’s study on mechanotransduction events in the afferent terminal is out on bioRxiv!
Ziolkowski LH, Gracheva EO, Bagriantsev SN. Mechanotransduction events at the physiological site of touch detection. bioRxiv 2022-10-24, https://doi.org/10.1101/2022.10.23.513402.
A nice report covering Rafael’s recent paper is published in J Exp Biol:
Ground squirrels hibernate through puberty by Brittney G. Borowiec
Congratulations!
Rafael’s review is published in Current Biology!
Dai Pra R, Bagriantsev SN, Gracheva EO. Quick guide: Ground squirrels. Curr Biol 2022, 32,R589-683.
Our recent review on the sense of touch is on the cover of the latest issue of Current Opinion in Neurobiology!
Our review on mechanosensitivity from the perspective of tactile specialist birds is out in Current Opinion in Neurobiology!
Ziolkowski LH, Gracheva EO, Bagriantsev SN. Tactile sensation in birds: Physiological insights from avian mechanoreceptors. Curr Opin Neurobiol 2022, 74: 102548.
Our Current Biology paper is now supplemented with a video Abstract featuring all the authors!
Our new study on sexual maturation during hibernation is out in Current Biology!
Dai Pra R, Mohr SM, Merriman DK, Bagriantsev SN, Gracheva EO. Ground squirrels initiate sexual maturation during hibernation. Curr Biol 2022, e-pub 3/3/2022.
Our recent review on the neural origins of hibernation is on the cover of J Exp Biol!
All that’s known about neural origins of hibernation is in our new review!
Junkins MS, Gracheva EO, Bagriantsev SN. Towards understanding the neural origin of hibernation. J Exp Biol 2022, 225 (1): jeb229542.
Our lab’s highlight of the great discoveries by David Julius and Ardem Patapoutian that earned them the Nobel Prize in 2021 is out in Cell!
Gracheva EO, Bagriantsev SN. Sensational Channels. Cell 2021, 184(26): 6213-16.
Our collaborative study with the Sobolevsky lab is out in Nature Communications!
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12(1):2154.
Our new study is out in Science Advances!
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6(51):eabe6393.
Our review on hibernation is out in Ann Rev Cell Dev Biol!
Mohr SM, Bagriantsev SN, Gracheva EO. Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges. Ann Rev Cell Dev Biol 2020, 36: e-pub Sept 08, 2020.
Congratulations, Sarah!
We posted our first preprint on BioRxiv on mechanosensitivty of Pacinian and Meissner Corpsucles!
Nikolaev YA, Feketa VV, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. BioRxiv 2020.2008.2024.265231.
Our new study is out in eLife!
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. eLife 2020, 9:e55370.
Our study on the mechanism of survival without water is on the cover of today’s Current Biology!
Video abstract
Our new paper of how hibernating squirrels manage to not drink for months is out in Current Biology!
Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO. Osmolyte depletion and thirst suppression allow hibernators to survive for months without water. Curr Biol 2019, e-pub 09/05/19.
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