A new paper from our lab is out in eLife. Congratulations to Wang!

Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. eLife 2019, 8:e44003.

A collaborative study between Elena and David Julius’ group is published in PNAS.

Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. PNAS 2018, e-pub 11/21/2018.

Our new paper on excitability of sensory neurons during hibernation is out in Current Biology!

Hoffstaetter LJ*, Mastrotto M*, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory neurons enter a state of altered excitability during hibernation. Curr Biol 2018, e-pub 08/30/18. *co-authors.

See our lab’s dispatch in Current Biology to a great paper by Harold Zakon’s group on fine-tuning of potassium channels in electric fish.

Gracheva EO, Bagriantsev SN. Communication: Potassium channels define the dialect. Curr Biol 2018, 28(13): R744-6.

Our new paper on TMEM150C, Piezo1/2 and TREK-1 is out in Cell Reports!

Anderson EO, Schneider ER, Matson JD, Gracheva EO, Bagriantsev SN. TMEM150C / Tentonin3 is a regulator of mechano-gated ion channels. Cell Reports 2018, 23(3): 701-708.

Lydia’s review is out in Pflugers Archiv!

Hoffstaetter LJ, Bagriantsev SN, Gracheva EO. TRPs et al.: a molecular toolkit for thermosensory adaptations. Pflügers Archiv 2018, e-pub 02/27/2018.

Our new paper on Piezo2 and mechanosensitivity in duck trigeminal neurons is out in PNAS!

Schneider E*, Anderson E*, Mastrotto M, Matson J, Schulz V, Gallagher P, LaMotte R, Gracheva E, Bagriantsev S. Molecular basis of tactile specialization in the duck bill. PNAS 2017, 114(49): 13036-41. *co-authors

Watch a movie taken by Eve showing mechanoreceptive corpuscle density in the skin of the duck bill. Stunning!

A collaborative study with the Pat Gallagher lab is published!

Glogowska E, Schneider E, Maksimova Y, Schulz V, Lezon-Geyda K, Wu J, Radhakrishnan K, Keel S, Mahoney D, Freidman A, Altura R, Gracheva E, Bagriantsev S, Kalfa T, Gallagher P. Novel mechanisms of PIEZO1 dysfunction in Hereditary Xerocytosis. Blood 2017, 130(16):1845-1856.

Our paper on TRPV1 from heat-resistant animals is out in PNAS!

Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. PNAS 2016, 113(40): 11342-47.

A review on the mechanosensitivity in tactile specialists is out in Physiology:

Schneider ER, Gracheva EO, Bagriantsev SN. Evolutionary specialization of tactile perception in vertebrates. Physiology 2016, 31(3):193-200.

Elena’s collaboration with Polina Lishko is published in Science:

Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signalling governs sperm activation via sex hormone progesterone. Science 2016, Apr29;352(6285):555-9.

Our review on TRPA1 is out in Temperature!

Laursen WJ, Anderson EO, Hoffstaetter L, Bagriantsev SN, Gracheva EO. Species-specific temperature sensitivity of TRPA1. Temperature 2015, 2:1-13.

Authors: Lydia, Willem, Evan, Slav, Elena.

in Current Opinion in Neurobiology.

Gracheva EO, Bagriantsev SN. Evolutionary adaptation to thermosensation. Curr Opin Neurobiol 2015, 34:67-73.

A new publication from our Labs!

Laursen WJ, Mastrotto M, Pesta D, Funk O, Goodman J, Merriman D, Ingolia N, Shulman G, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during torpor. PNAS 2015 (e-pub 01/20).

Warm brains rule!

A review from the labs is out in the Journal of Physiology!

Bagriantsev SN, Gracheva EO. Molecular mechanisms of temperature adaptation. J Physiol 2014 (e-pub 11/28).

This is the fourth review this year from the Slav and Elena groups.

Yes, we have a lot to say.

Two papers from our labs are published in vol. 74 of Current Topics in Membranes!

Laursen WJ, Bagriantsev SN, Gracheva EO. TRPA1 channels: chemical and temperature sensitivity. Curr Top Membr (Thermal sensors) 2014, 74:89-112.

Schneider ER, Anderson EO, Gracheva EO, Bagriantsev SN. Temperature sensitivity of two-pore (K2P) potassium channels. Curr Top Membr (Thermal sensors) 2014, 74: 111-133.

Our review on Piezo proteins is published in JBC!

Bagriantsev SN, Gracheva EO, Gallagher PG. Piezo proteins: regulators of mechanosensation and other cellular processes. J Biol Chem (2014) e-pub Oct 10.

The first research publication from the Slav and Elena Labs at Yale is finally out:

Schneider ER., Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. PNAS (2014) e-pub Sep. 22.

Congratulations to everyone involved!

Special thanks to Margaret Rubega, Kristof Zyskowski, Kenny Dahill, Tina Hotchkiss, Jeffrey Laursen and Charles Pederson for their invaluable input at different stages of this study.

A collaboration with the DeCamilli lab results in the first publication from the Slav and Elena Labs at Yale – in Cell!