Our collaborative study with the Sobolevsky lab is out in Nature Communications!
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12(1):2154.
Our new study is out in Science Advances!
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6(51):eabe6393.
Our review on hibernation is out in Ann Rev Cell Dev Biol!
Mohr SM, Bagriantsev SN, Gracheva EO. Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges. Ann Rev Cell Dev Biol 2020, 36: e-pub Sept 08, 2020.
Congratulations, Sarah!
We posted our first preprint on BioRxiv on mechanosensitivty of Pacinian and Meissner Corpsucles!
Nikolaev YA, Feketa VV, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. BioRxiv 2020.2008.2024.265231.
Our new study is out in eLife!
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. eLife 2020, 9:e55370.
Our study on the mechanism of survival without water is on the cover of today’s Current Biology!
Video abstract
Our new paper of how hibernating squirrels manage to not drink for months is out in Current Biology!
Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO. Osmolyte depletion and thirst suppression allow hibernators to survive for months without water. Curr Biol 2019, e-pub 09/05/19.
A new study from our lab on how cold affects mechanoreceptor function is out in PNAS!
Zheng W, Nikolaev TA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. PNAS 2019, 116(35): 17547-17555.
Slav and Elena finished editing a Special Issue of Neuroscience Letters on thermoregulation. The issue features a great collection of reviews from experts in the field.
Editorial:
Gracheva EO, Bagriantsev SN. Neural mechanisms of thermoregulation. Neurosci Letters 2019, Jun 3;707:134318.
A new study on the role of Piezo2 in mechanosensory specialization of trigeminal neurons is out on the cover of Cell Reports!
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A cross-species analysis reveals a common strategy for mechanosensory specialization in trigeminal ganglia. Cell Reports 2019, 26(8): 1979-1987.
UPD: an interesting viewpoint on our study on “Why Evolution is True” by Matthew Cobb: Duck beaks, Umwelt and Kantian a prioris
UPD2: More press coverage on this story (also presented at Biophysical Meeting 2019): EurekAlert, Lab Manager, Phys.Org, Earth.com, Laboratoryequipment.com, also International: 20 minutos, infosalus.com, Diario de Navarra, PlanetaIncognito (Spanish), Tekk.tv (German).
UPD3: A recommendation by Ilya Ruvinsky on F1000: Neuro-Eco-Evo-Devo.
A new paper from our lab is out in eLife. Congratulations to Wang!
Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. eLife 2019, 8:e44003.
A collaborative study between Elena and David Julius’ group is published in PNAS.
Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. PNAS 2018, e-pub 11/21/2018.
A great commentary on Lydia and Marco’s recent paper in Current Biology is published in Journal of Experimental Biology:
Daniel Vahaba Hibernating squirrels tweak sodium channels to rest their brain. (pdf)
Congratulations!
Our new paper on excitability of sensory neurons during hibernation is out in Current Biology!
Hoffstaetter LJ*, Mastrotto M*, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory neurons enter a state of altered excitability during hibernation. Curr Biol 2018, e-pub 08/30/18. *co-authors.
See our lab’s dispatch in Current Biology to a great paper by Harold Zakon’s group on fine-tuning of potassium channels in electric fish.
Gracheva EO, Bagriantsev SN. Communication: Potassium channels define the dialect. Curr Biol 2018, 28(13): R744-6.
Our new paper on TMEM150C, Piezo1/2 and TREK-1 is out in Cell Reports!
Anderson EO, Schneider ER, Matson JD, Gracheva EO, Bagriantsev SN. TMEM150C / Tentonin3 is a regulator of mechano-gated ion channels. Cell Reports 2018, 23(3): 701-708.
Lydia’s review is out in Pflugers Archiv!
Hoffstaetter LJ, Bagriantsev SN, Gracheva EO. TRPs et al.: a molecular toolkit for thermosensory adaptations. Pflügers Archiv 2018, e-pub 02/27/2018.
Our paper on TRPM8 in hibernating animals is published in Cell Reports and featured on the cover!
Matos-Cruz V, Schneider E, Mastrotto M, Merriman D, Bagriantsev S, Gracheva E. Molecular prerequisites for diminished cold sensitivity in ground squirrels and hamsters. Cell Reports 2017, 21(12): 3329-37.
Our paper on Piezo2 and duckbill mechanosensitivity is featured on the cover of today’s issue of PNAS! Special thanks to Ryan Dunn for providing the photo.
A great commentary in PNAS by Ruhma Syeda on our latest paper on the sense of touch in duck neurons!
Our new paper on Piezo2 and mechanosensitivity in duck trigeminal neurons is out in PNAS!
Schneider E*, Anderson E*, Mastrotto M, Matson J, Schulz V, Gallagher P, LaMotte R, Gracheva E, Bagriantsev S. Molecular basis of tactile specialization in the duck bill. PNAS 2017, 114(49): 13036-41. *co-authors
Watch a movie taken by Eve showing mechanoreceptive corpuscle density in the skin of the duck bill. Stunning!
A collaborative study with the Pat Gallagher lab is published!
Glogowska E, Schneider E, Maksimova Y, Schulz V, Lezon-Geyda K, Wu J, Radhakrishnan K, Keel S, Mahoney D, Freidman A, Altura R, Gracheva E, Bagriantsev S, Kalfa T, Gallagher P. Novel mechanisms of PIEZO1 dysfunction in Hereditary Xerocytosis. Blood 2017, 130(16):1845-1856.
A review on Piezo2 in vertebrate mechanoreception in vertebrates is out!
Finding Evan takes on a new meaning…
Anderson EO, Schneider ER, Bagriantsev SN. Piezo2 in cutaneous and proprioceptive mechanotransduction in vertebrates. Curr Top Membr (Piezo channels) 2017, 79: 197-217.
Our recent paper has been highlighted on the PNAS website!
Our paper on TRPV1 from heat-resistant animals is out in PNAS!
Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. PNAS 2016, 113(40): 11342-47.
A review on the mechanosensitivity in tactile specialists is out in Physiology:
Schneider ER, Gracheva EO, Bagriantsev SN. Evolutionary specialization of tactile perception in vertebrates. Physiology 2016, 31(3):193-200.
Elena’s collaboration with Polina Lishko is published in Science:
Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signalling governs sperm activation via sex hormone progesterone. Science 2016, Apr29;352(6285):555-9.
Our review on TRPA1 is out in Temperature!
Laursen WJ, Anderson EO, Hoffstaetter L, Bagriantsev SN, Gracheva EO. Species-specific temperature sensitivity of TRPA1. Temperature 2015, 2:1-13.
Authors: Lydia, Willem, Evan, Slav, Elena.
in Current Opinion in Neurobiology.
Gracheva EO, Bagriantsev SN. Evolutionary adaptation to thermosensation. Curr Opin Neurobiol 2015, 34:67-73.
A new publication from our Labs!
Laursen WJ, Mastrotto M, Pesta D, Funk O, Goodman J, Merriman D, Ingolia N, Shulman G, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during torpor. PNAS 2015 (e-pub 01/20).
Warm brains rule!
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