Our paper on the structure and functional mechanism in Meissner corpuscle is out in Science Advances!
Nikolaev YA*, Ziolkowski LH*, Pang S, Li W-P, Feketa VV, Xu CS, Gracheva, EO, Bagriantsev SN. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle. Science Advances, 2023, 9:eadi4147.
Our review on thermoregulation in hibernators is out in Trends in Neuroscience!
Feketa VV, Bagriantsev SN, Gracheva EO. Ground squirrels — experts in thermoregulatory adaptation. Trends in Neurosciences 2023, https://doi.org/10.1016/j.tins.2023.04.008
Mai and Yury’s collaborative work with the Sobolevsky lab is out in Nature Communications!
Neuberger A, Oda M, Nikolaev YA, Nadezhdin KD, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14, 2451.
A new pre-print from our lab by Yury and Luke reports the structure of Meissner corpuscle and the amazing bi-cellular mechanism by which corpuscles detect touch.
Nikolaev YA, Ziolkowski LH, Pang S, Li W-P, Feketa VV, Xu CS, Gracheva, EO, Bagriantsev SN*. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle. (2023) bioRxiv doi.org/10.1101/2023.04.05.535701.
A new study by Sarah Mohr is out on BioRxiv!
Mohr SM, Dai Pra R, Platt MP, Feketa VV, Shanabrough M, Varela L, Kristant A, Cao H, Merriman DK, Horvath TL, Bagriantsev SN, Gracheva EO. Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator. bioRxiv 2023.03.15.532843; doi: https://doi.org/10.1101/2023.03.15.532843
Our paper on mechanotransduction in the afferent terminal is highlighted by eLife!
Luke’s study on mechanotransduction in nerve terminals is out in eLife!
Ziolkowski LH, Gracheva EO, Bagriantsev SN. Mechanotransduction events at the physiological site of touch detection. eLife 2023, 12:e84179.
Luke’s study on mechanotransduction events in the afferent terminal is out on bioRxiv!
Ziolkowski LH, Gracheva EO, Bagriantsev SN. Mechanotransduction events at the physiological site of touch detection. bioRxiv 2022-10-24, https://doi.org/10.1101/2022.10.23.513402.
A nice report covering Rafael’s recent paper is published in J Exp Biol:
Ground squirrels hibernate through puberty by Brittney G. Borowiec
Congratulations!
Rafael’s review is published in Current Biology!
Dai Pra R, Bagriantsev SN, Gracheva EO. Quick guide: Ground squirrels. Curr Biol 2022, 32,R589-683.
Our recent review on the sense of touch is on the cover of the latest issue of Current Opinion in Neurobiology!
Our review on mechanosensitivity from the perspective of tactile specialist birds is out in Current Opinion in Neurobiology!
Ziolkowski LH, Gracheva EO, Bagriantsev SN. Tactile sensation in birds: Physiological insights from avian mechanoreceptors. Curr Opin Neurobiol 2022, 74: 102548.
Our Current Biology paper is now supplemented with a video Abstract featuring all the authors!
Our new study on sexual maturation during hibernation is out in Current Biology!
Dai Pra R, Mohr SM, Merriman DK, Bagriantsev SN, Gracheva EO. Ground squirrels initiate sexual maturation during hibernation. Curr Biol 2022, e-pub 3/3/2022.
Our recent review on the neural origins of hibernation is on the cover of J Exp Biol!
All that’s known about neural origins of hibernation is in our new review!
Junkins MS, Gracheva EO, Bagriantsev SN. Towards understanding the neural origin of hibernation. J Exp Biol 2022, 225 (1): jeb229542.
Our lab’s highlight of the great discoveries by David Julius and Ardem Patapoutian that earned them the Nobel Prize in 2021 is out in Cell!
Gracheva EO, Bagriantsev SN. Sensational Channels. Cell 2021, 184(26): 6213-16.
Our collaborative study with the Sobolevsky lab is out in Nature Communications!
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12(1):2154.
Our new study is out in Science Advances!
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6(51):eabe6393.
Our review on hibernation is out in Ann Rev Cell Dev Biol!
Mohr SM, Bagriantsev SN, Gracheva EO. Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges. Ann Rev Cell Dev Biol 2020, 36: e-pub Sept 08, 2020.
Congratulations, Sarah!
We posted our first preprint on BioRxiv on mechanosensitivty of Pacinian and Meissner Corpsucles!
Nikolaev YA, Feketa VV, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. BioRxiv 2020.2008.2024.265231.
Our new study is out in eLife!
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. eLife 2020, 9:e55370.
Our study on the mechanism of survival without water is on the cover of today’s Current Biology!
Video abstract
Our new paper of how hibernating squirrels manage to not drink for months is out in Current Biology!
Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO. Osmolyte depletion and thirst suppression allow hibernators to survive for months without water. Curr Biol 2019, e-pub 09/05/19.
A new study from our lab on how cold affects mechanoreceptor function is out in PNAS!
Zheng W*, Nikolaev YA*, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. PNAS 2019, 116(35): 17547-17555.
Slav and Elena finished editing a Special Issue of Neuroscience Letters on thermoregulation. The issue features a great collection of reviews from experts in the field.
Editorial:
Gracheva EO, Bagriantsev SN. Neural mechanisms of thermoregulation. Neurosci Letters 2019, Jun 3;707:134318.
A new study on the role of Piezo2 in mechanosensory specialization of trigeminal neurons is out on the cover of Cell Reports!
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A cross-species analysis reveals a common strategy for mechanosensory specialization in trigeminal ganglia. Cell Reports 2019, 26(8): 1979-1987.
UPD: an interesting viewpoint on our study on “Why Evolution is True” by Matthew Cobb: Duck beaks, Umwelt and Kantian a prioris
UPD2: More press coverage on this story (also presented at Biophysical Meeting 2019): EurekAlert, Lab Manager, Phys.Org, Earth.com, Laboratoryequipment.com, also International: 20 minutos, infosalus.com, Diario de Navarra, PlanetaIncognito (Spanish), Tekk.tv (German).
UPD3: A recommendation by Ilya Ruvinsky on F1000: Neuro-Eco-Evo-Devo.
A new paper from our lab is out in eLife. Congratulations to Wang!
Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. eLife 2019, 8:e44003.
A collaborative study between Elena and David Julius’ group is published in PNAS.
Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. PNAS 2018, e-pub 11/21/2018.
A great commentary on Lydia and Marco’s recent paper in Current Biology is published in Journal of Experimental Biology:
Daniel Vahaba Hibernating squirrels tweak sodium channels to rest their brain. (pdf)
Congratulations!
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