Sensory Physiology Labs at Yale

Collaborative projects between Slav Bagriantsev and Elena Gracheva Laboratories at Yale University

Category: Publications (page 1 of 2)

Current Biology

Maddy and Jenny’s paper on the neural control of fluid homeostasis during hibernation is out in Current Biology!

Junkins MS*, Feng NY*, Murphy LA, Curtis G, Merriman DK, Bagriantsev SN, Gracheva EO. Neural control of fluid homeostasis is engaged below 10°C in hibernation. Current Biology 2024, 34, 1-8.

Science Advances

Our paper on the structure and functional mechanism in Meissner corpuscle is out in Science Advances!

Nikolaev YA*, Ziolkowski LH*, Pang S, Li W-P, Feketa VV, Xu CS, Gracheva, EO, Bagriantsev SN. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle. Science Advances, 2023, 9:eadi4147.

 

Trends in Neurosciences

Our review on thermoregulation in hibernators is out in Trends in Neuroscience!

Feketa VV, Bagriantsev SN, Gracheva EO. Ground squirrels — experts in thermoregulatory adaptation. Trends in Neurosciences 2023, https://doi.org/10.1016/j.tins.2023.04.008

Nature Communications

Mai and Yury’s collaborative work with the Sobolevsky lab is out in Nature Communications!

Neuberger A, Oda M, Nikolaev YA, Nadezhdin KD, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14, 2451.

BioRxiv

A new pre-print from our lab by Yury and Luke reports the structure of Meissner corpuscle and the amazing bi-cellular mechanism by which corpuscles detect touch.

Nikolaev YA, Ziolkowski LH, Pang S, Li W-P, Feketa VV, Xu CS, Gracheva, EO, Bagriantsev SN*. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle. (2023) bioRxiv doi.org/10.1101/2023.04.05.535701.

BioRxiv

A new study by Sarah Mohr is out on BioRxiv!

Mohr SM, Dai Pra R, Platt MP, Feketa VV, Shanabrough M, Varela L, Kristant A, Cao H, Merriman DK, Horvath TL, Bagriantsev SN, Gracheva EO. Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator. bioRxiv 2023.03.15.532843; doi: https://doi.org/10.1101/2023.03.15.532843

Getting to grips with touch

Our paper on mechanotransduction in the afferent terminal is highlighted by eLife!

Photo

eLife

Luke’s study on mechanotransduction in nerve terminals is out in eLife!

Ziolkowski LH, Gracheva EO, Bagriantsev SN. Mechanotransduction events at the physiological site of touch detection. eLife 2023, 12:e84179.

BioRxiv

Luke’s study on mechanotransduction events in the afferent terminal is out on bioRxiv!

Ziolkowski LH, Gracheva EO, Bagriantsev SN. Mechanotransduction events at the physiological site of touch detection. bioRxiv 2022-10-24, https://doi.org/10.1101/2022.10.23.513402.

Rafael’s paper is covered in J Exp Biol

A nice report covering Rafael’s recent paper is published in J Exp Biol:

Ground squirrels hibernate through puberty by Brittney G. Borowiec

Congratulations!

Current Biology

Rafael’s review is published in Current Biology!

Dai Pra R, Bagriantsev SN, Gracheva EO. Quick guide: Ground squirrels. Curr Biol 2022, 32,R589-683.

Curr Opin Neurobiol Cover

Our recent review on the sense of touch is on the cover of the latest issue of Current Opinion in Neurobiology!

Current Opinion in Neurobiology

Our review on mechanosensitivity from the perspective of tactile specialist birds is out in Current Opinion in Neurobiology!

Ziolkowski LH, Gracheva EO, Bagriantsev SN.  Tactile sensation in birds: Physiological insights from avian mechanoreceptors. Curr Opin Neurobiol 2022, 74: 102548.

Video abstract for our Current Biology paper

Our Current Biology paper is now supplemented with a video Abstract featuring all the authors!

Current Biology

Our new study on sexual maturation during hibernation is out in Current Biology!

Dai Pra R, Mohr SM, Merriman DK, Bagriantsev SN, Gracheva EO. Ground squirrels initiate sexual maturation during hibernation. Curr Biol 2022, e-pub 3/3/2022.

J Exp Biol Cover

Our recent review on the neural origins of hibernation is on the cover of J Exp Biol!

Journal of Experimental Biology

All that’s known about neural origins of hibernation is in our new review!

Junkins MS, Gracheva EO, Bagriantsev SN. Towards understanding the neural origin of hibernation. J Exp Biol 2022, 225 (1): jeb229542.

Cell

Our lab’s highlight of the great discoveries by David Julius and Ardem Patapoutian that earned them the Nobel Prize in 2021 is out in Cell!

Gracheva EO, Bagriantsev SN. Sensational Channels. Cell 2021, 184(26): 6213-16.

Nature Communications

Our collaborative study with the Sobolevsky lab is out in Nature Communications!

Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12(1):2154.

Science Advances

Our new study is out in Science Advances!

Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6(51):eabe6393.

Ann Rev Cell Dev Biol

Our review on hibernation is out in Ann Rev Cell Dev Biol!

Mohr SM, Bagriantsev SN, Gracheva EO. Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges. Ann Rev Cell Dev Biol 2020, 36: e-pub Sept 08, 2020.

Congratulations, Sarah!

Our first preprint on BioRxiv

We posted our first preprint on BioRxiv on mechanosensitivty of Pacinian and Meissner Corpsucles!

Nikolaev YA, Feketa VV, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. BioRxiv 2020.2008.2024.265231.

eLife

Our new study is out in eLife!

Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. eLife 2020, 9:e55370.

Current Biology Cover!

Our study on the mechanism of survival without water is on the cover of today’s Current Biology!

Video abstract

Current Biology

Our new paper of how hibernating squirrels manage to not drink for months is out in Current Biology!

Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO. Osmolyte depletion and thirst suppression allow hibernators to survive for months without water. Curr Biol 2019, e-pub 09/05/19.

PNAS

A new study from our lab on how cold affects mechanoreceptor function is out in PNAS!

Zheng W*, Nikolaev YA*, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors.  PNAS 2019, 116(35): 17547-17555.

Neuroscience Letters

Slav and Elena finished editing a Special Issue of Neuroscience Letters on thermoregulation. The issue features a great collection of reviews from experts in the field.

Editorial:

Gracheva EO, Bagriantsev SN. Neural mechanisms of thermoregulation. Neurosci Letters 2019, Jun 3;707:134318.

Cell Reports

A new study on the role of Piezo2 in mechanosensory specialization of trigeminal neurons is out on the cover of Cell Reports!

Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A cross-species analysis reveals a common strategy for mechanosensory specialization in trigeminal ganglia. Cell Reports 2019, 26(8): 1979-1987.

UPD: an interesting viewpoint on our study on “Why Evolution is True” by Matthew Cobb: Duck beaks, Umwelt and Kantian a prioris

UPD2: More press coverage on this story (also presented at Biophysical Meeting 2019): EurekAlert, Lab Manager, Phys.Org, Earth.com, Laboratoryequipment.com, also International: 20 minutosinfosalus.com, Diario de Navarra, PlanetaIncognito (Spanish), Tekk.tv (German).

UPD3: A recommendation by Ilya Ruvinsky on F1000:  Neuro-Eco-Evo-Devo.

eLife

A new paper from our lab is out in eLife. Congratulations to Wang!

Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. eLife 2019, 8:e44003.

PNAS

A collaborative study between Elena and David Julius’ group is published in PNAS.

Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. PNAS 2018, e-pub 11/21/2018.

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