Welcome to Sibel Ebru Yalcin’s Research Page at Yale University.

Dr. Yalcin is a physicist and spectroscopist who specializes in biological imaging. During her postdoc at PNNL, she has developed a new capability to perform Infrared Spectroscopy at nanoscale on individual microbial protein nanowires and water reactive mineral surfaces. She has worked to perform label free nano scale IR imaging for biological molecules and environmental materials under their physiologically relevant conditions such as pH and humidity. Her structural studies led to the discoveries of atomic structure of conductive “Geobacter” OmcS nanowires (Cell, 2019) and electric field stimulated production of 1000 times more conductive OmcZ nanowires (Nature Chemical Biology, 2020). Discovery of cytochrome OmcZ nanowires explains the mystery of high biofilm conductivity scientists observed even in the absence of cytochrome OmcS! Highlights to our work can be found at Nature Chemical Biology News and Views article, LiveScience,  YaleNews and Yale’s Microbial Sciences Institute. Proteopedia selected Geobacter’s microbial cytochrome nanowires as the most influential structure discovered in the 21st century http://proteopedia.org/wiki/index.php/Highest_impact_structures?fbclid=IwAR3PDQneRhrypWZmgGTDRkFLOjo0s96MZtnAnYGNw0SQ6OOB1bVQ_vlF47Y#21st_Century

Other than biological systems, Dr. Yalcin performed the first Nanoscale Chemical Imaging on reactive minerals (Gibbsite, Lepidocrocite) through their water binding chemistry. Her studies are critical to understand how mineral morphology plays critical role on water chemistry (Science Advances, 2020). Highlights to this work can be found at Yale West Campus, Yale’s Microbial Sciences Institute, Yale’s MB&B News​​ and Umea University.

Dr. Yalcin has considerable experiences in Ultrafast Spectroscopy and Nanoscale Near-field Imaging of many low dimensional systems. Prior to PNNL, she was a part of user facility at Los Alamos National Laboratory (LANL) where she built single molecule spectroscopy setup to study Carbon Nanotubes (Nanoscale, 2015) with Steve Doorn and other low dimension materials such as Graphene Oxide (ACS Nano, 2015), MoS2 (Nature Materials, 2014) with Manish Chhowalla. At University of Massachusetts Amherst, Dr. Yalcin has developed an Electrostatic Force Microscopy (EFM) based imaging method that has enabled the first visualization of electron transport in individual bacterial protein nanowires under biologically relevant conditions (Nature Nanotechnology, 2014) with Nikhil Malvankar & Derek Lovley.

Dr. Yalcin holds a research faculty position at Yale’s Department of Molecular Biophysics & Biochemistry and Microbial Sciences Institute. She leads the effort of nanoscale functional imaging research to understand structural, physical and biochemical components and pathways involved in biological electron transfer. She has PhD in Physics, and extensive experience in Biochemistry, Geochemistry and Microbiology.

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