The team

Kuldeepkumar Gupta, PhD. Kuldeep is a postdoc in the lab. He obtained his B.Sc. in Biotechnology from University of Mumbai, India in 2008. Subsequently, he joined Indian Institute of Science (IISc), Bangalore,India for an Integrated Masters and Ph.D. program in the Division of Biological Sciences. In IISc, he worked with Prof. Dipankar Chatterji at the Molecular Biophysics Unit. During his doctoral studies, he studied the regulation of biofilm formation, antibiotic resistance, cell shape and cell division by nucleotide second messengers (p)ppGpp and c-di-GMP in Mycobacterium smegmatis. He is intrigued by the phenotypic heterogeneity exhibited by bacteria which is one the underlying causes of antibiotic resistance shown by bacteria. In the Rego lab, he is currently exploring the mechanisms governing the bacterial phenotypic heterogeneity using mycobacteria as the model system.

Celena Gwin, Graduate Student. Celena earned her Bachelor’s degree at Hofstra University. There, she spent time training under Nathan Rigel to learn about bacterial genetics and protein sorting and secretion in the outer membrane of gram negative bacteria. Currently, she is a graduate student in the Microbial Pathogenesis department hoping to learn about the fascinating aspects of asymmetrical cell division in mycobacteria.

Yao Lu, Graduate Student. Yao obtained her Bachelor’s degree at Tsinghua University in Beijing, China. During undergrad she worked in Dr. Gong Cheng’s lab on how Dengue virus tackles and evades the immune responses of mosquitoes. Upon joining the Microbiology PhD program at Yale, Yao discovered the charm of bacteriology and microscopy (Yay!) and is now very excited to explore the single cell biology of mycobacteria using (and maybe developing) a variety of microscopy techniques.

Wei Ng, Graduate StudentWei obtained her Bachelor’s degree at the University of Pittsburgh in Biological Sciences. As an undergraduate, she worked in Graham Hatfull’s lab studying a mycobacteriophage chromosome partitioning system and phage-encoded toxic small RNAs. She is a graduate student in Microbial Pathogenesis, and can’t wait to delve into bacterial phenotypic heterogeneity and mycobacterial cell biology, armed with a microscope (Hesper gives virtual high-five!)!

Hesper Rego, PhD. Hesper trained as physicist in both her undergraduate and graduate studies. She did her graduate work with the late Mats Gustafsson at UCSF and Janelia Farm. In his group, she developed a nonlinear form of Structured-Illumination Microscopy. Afterwards, wanting to explore a biological phenomenon she did her postdoctoral work with Eric Rubin at the Harvard School of Public Health where she became fascinated by the ability of genetically identical organisms to display different phenotypes. This phenomenon is especially important for the treatment of tuberculosis, a disease caused by the bacterial pathogen Mycobacterium tuberculosis. She is excited to start a research group at the intersection of these two areas: the application of advanced light microscopy techniques to investigate the strategies mycobacteria use to survive the stresses imposed by the antibiotics and the host.

Lin Shao, PhD. Lin is a research associate in the lab and splits his time between our lab and 3 others at the Yale School of Medicine. He obtained his PhD in the lab of John Sedat at UCSF. There, he worked with Mats Gustafsson, pushing structured-illumination microscopy into three dimensions. He went on to do postdoctoral training in the labs of Mats Gustafssson and Eric Betzig at Janelia Farm.  For the Rego Lab he is designing and building a custom SLM-based 3D SIM.

Former trainees

Kasia Baranowski, PhD. Scientist, Zymergen.

Maikel Boot, PhD. Amsterdam, the Netherlands.

Ali Farinas. Undergrad, Amherst College.

Sam Zinga. MD/PhD student,  Harvard.