Welcome to the Yan Lab@Yale School of Medicine!

Our laboratory is interested in understanding how epigenetic aberrations cause cancer and other human diseases. In particular, we focus on the roles and regulatory mechanisms of epigenetic regulators including KDM5 histone demethylases, bromodomain proteins CECR2 and BRD4. Our recent studies suggest that they are potential drug targets for cancer therapy and we have identified specific inhibitors of these proteins.

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