Thoreen Laboratory

Cellular and Molecular Physiology / Yale University

Publications

(search pubmed for a complete listing)

  1. Philippe L, van den Elzen AMG, Watson, MJ, Thoreen CC. (2020) Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5’ TOP Motifs. Proc Natl Acad Sci U S A. Feb 24. PMCID: pending.
  2. Philippe L, Vasseur JJ, Debart F, Thoreen CC. (2017) La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. Nucleic Acids Res. Dec 13. doi: 10.1093/nar/gkx1237. PMCID: PMC5814973.
  3. Park Y, Reyna-Neyra A, Philippe L, Thoreen CC. (2017). mTORC1 balances cellular amino acid supply with demand for protein synthesis through post-transcriptional control of Atf4. Cell Rep. 2017 May 9;19(6):1083-1090. PMCID: PMC5811220.
  4. Thoreen CC. The molecular basis of mTORC1-regulated translation. (2017) Biochem Soc Trans. Feb 8; 45(1):213-221.
  5. Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM. (2012). A unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 485:109-13.
  6. Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS. (2012). Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 287:9742-52.
  7. Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. (2009). DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 137:873-86.
  8. Thoreen CC, Sabatini DM. (2009). Rapamycin inhibits mTORC1, but not completely.Autophagy. 5:725-6.
  9. Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, and Gray NS. (2009). An ATP-competitive inhibitor reveals rapamycin-insensitive functions of mTORC1. J Biol Chem. 284:8023-32.
  10. Sancak Y*, Thoreen CC*, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. (2007). PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 25:903-15.
  11. Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. (2006). Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 11:859-71.
  12. Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM. (2006). mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol. 16:1865-70.
  13. Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM. (2006). Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol. 16:958-70.
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