Our review on hibernation is out in Ann Rev Cell Dev Biol!
Mohr SM, Bagriantsev SN, Gracheva EO.
Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges. 2020, 36: e-pub Sept 08, 2020. Ann Rev Cell Dev Biol
We posted our first preprint on BioRxiv on mechanosensitivty of Pacinian and Meissner Corpsucles!
Nikolaev YA, Feketa VV, Gracheva EO, Bagriantsev SN.
Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. BioRxiv 2020.2008.2024.265231.
Our new study is out in eLife!
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO.
CNGA3 acts as a cold sensor in hypothalamic neurons. 2020, 9:e55370. eLife
study on the mechanism of survival without water is on the cover of today’s Current Biology!
Our new paper of how hibernating squirrels manage to not drink for months is out in Current Biology!
Feng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO.
Osmolyte depletion and thirst suppression allow hibernators to survive for months without water. 2019, e-pub 09/05/19. Curr Biol
A new study from our lab on how cold affects mechanoreceptor function is out in PNAS!
Zheng W, Nikolaev TA, Gracheva EO, Bagriantsev SN.
Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. 2019, 116(35): 17547-17555. PNAS
Slav and Elena finished editing a Special Issue of Neuroscience Letters on thermoregulation. The issue features a
great collection of reviews from experts in the field.
Gracheva EO, Bagriantsev SN.
Neural mechanisms of thermoregulation. 2019, Jun 3;707:134318. Neurosci Letters
A new study on the role of Piezo2 in mechanosensory specialization of trigeminal neurons is out on the cover of Cell Reports!
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN.
A cross-species analysis reveals a common strategy for mechanosensory specialization in trigeminal ganglia. 2019, 26(8): 1979-1987. Cell Reports
UPD: an interesting viewpoint on our study on “Why Evolution is True” by Matthew Cobb: Duck beaks, Umwelt and Kantian a prioris
UPD2: More press coverage on this story (also presented at
Biophysical Meeting 2019): EurekAlert, Lab Manager, Phys.Org, Earth.com, Laboratoryequipment.com, also International: 20 minutos, infosalus.com, Diario de Navarra, PlanetaIncognito (Spanish), Tekk.tv (German).
UPD3: A recommendation by Ilya Ruvinsky on F1000:
A collaborative study between Elena and
David Julius’ group is published in PNAS.
Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D.
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. 2018, e-pub 11/21/2018. PNAS
Our new paper on excitability of sensory neurons during hibernation is out in Current Biology!
Hoffstaetter LJ*, Mastrotto M*, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO.
Somatosensory neurons enter a state of altered excitability during hibernation. 2018, e-pub 08/30/18. Curr Biol *co-authors.
See our lab’s dispatch in Current Biology to a
great paper by Harold Zakon’s group on fine-tuning of potassium channels in electric fish.
Gracheva EO, Bagriantsev SN.
Communication: Potassium channels define the dialect. 2018, 28(13): R744-6. Curr Biol
Our new paper on TMEM150C, Piezo1/2 and TREK-1 is out in Cell Reports!
Anderson EO, Schneider ER, Matson JD, Gracheva EO, Bagriantsev SN.
TMEM150C / Tentonin3 is a regulator of mechano-gated ion channels. 2018, 23(3): 701-708. Cell Reports
Lydia’s review is out in Pflugers Archiv!
Hoffstaetter LJ, Bagriantsev SN, Gracheva EO.
TRPs et al.: a molecular toolkit for thermosensory adaptations. e-pub 02/27/2018. Pflügers Archiv 2018,
Our paper on TRPM8 in hibernating animals is published in Cell Reports and featured on the cover!
Matos-Cruz V, Schneider E, Mastrotto M, Merriman D, Bagriantsev S, Gracheva E.
Molecular prerequisites for diminished cold sensitivity in ground squirrels and hamsters . 2017, 21(12): 3329-37. Cell Reports
paper on Piezo2 and duckbill mechanosensitivity is featured on the cover of today’s issue of PNAS! Special thanks to Ryan Dunn for providing the photo.
commentary in PNAS by Ruhma Syeda on our latest paper on the sense of touch in duck neurons!
Our new paper on Piezo2 and mechanosensitivity in duck trigeminal neurons is out in PNAS!
*, Anderson E *, Mastrotto M, Matson J, Schulz V, Gallagher P, LaMotte R, Gracheva E, Bagriantsev S. Molecular basis of tactile specialization in the duck bill. 2017, 114(49): 13036-41. PNAS *co-authors
movie taken by Eve showing mechanoreceptive corpuscle density in the skin of the duck bill. Stunning!
A collaborative study with the Pat Gallagher lab is published!
Glogowska E, Schneider E, Maksimova Y, Schulz V, Lezon-Geyda K, Wu J, Radhakrishnan K, Keel S, Mahoney D, Freidman A, Altura R, Gracheva E, Bagriantsev S, Kalfa T, Gallagher P.
Novel mechanisms of PIEZO1 dysfunction in Hereditary Xerocytosis. 2017, 130(16):1845-1856. Blood
A review on Piezo2 in vertebrate mechanoreception in vertebrates is out!
Finding Evan takes on a new meaning…
Anderson EO, Schneider ER, Bagriantsev SN.
Piezo2 in cutaneous and proprioceptive mechanotransduction in vertebrates. (Piezo channels) 2017, 79: 197-217. Curr Top Membr
recent paper has been highlighted on the PNAS website!
Our paper on TRPV1 from heat-resistant animals is out in PNAS!
Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. PNAS 2016, 113(40): 11342-47.
A review on the mechanosensitivity in tactile specialists is out in Physiology:
Schneider ER, Gracheva EO, Bagriantsev SN.
Evolutionary specialization of tactile perception in vertebrates. 2016, 31(3):193-200. Physiology
Elena’s collaboration with
Polina Lishko is published in Science:
Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV.
Unconventional endocannabinoid signalling governs sperm activation via sex hormone progesterone. Science 2016, Apr29;352(6285):555-9.
Our review on TRPA1 is out in Temperature!
Laursen WJ, Anderson EO, Hoffstaetter L, Bagriantsev SN, Gracheva EO.
Species-specific temperature sensitivity of TRPA1. 2015, 2:1-13. Temperature
Authors: Lydia, Willem, Evan, Slav, Elena.
Current Opinion in Neurobiology.
Gracheva EO, Bagriantsev SN.
Evolutionary adaptation to thermosensation. 2015, 34:67-73. Curr Opin Neurobiol
A new publication from our Labs!
Laursen WJ, Mastrotto M, Pesta D, Funk O, Goodman J, Merriman D, Ingolia N, Shulman G, Bagriantsev SN, Gracheva EO.
Neuronal UCP1 expression suggests a mechanism for local thermogenesis during torpor. 2015 (e-pub 01/20). PNAS
Warm brains rule!
A review from the labs is out in the Journal of Physiology!
Bagriantsev SN, Gracheva EO. Molecular mechanisms of temperature adaptation.
J Physiol 2014 (e-pub 11/28).
This is the fourth review this year from the Slav and Elena groups.
Yes, we have a lot to say.
Two papers from our labs are published in vol. 74 of Current Topics in Membranes!
Laursen WJ, Bagriantsev SN, Gracheva EO. TRPA1 channels: chemical and temperature sensitivity.
Curr Top Membr (Thermal sensors) 2014, 74:89-112.
Schneider ER, Anderson EO, Gracheva EO, Bagriantsev SN. Temperature sensitivity of two-pore (K2P) potassium channels.
Curr Top Membr (Thermal sensors) 2014, 74: 111-133.